HORDB

ID: hor006446
Uniprot ID: P79695
Protein name: Glucagon-like peptide
Gene name: gcg
Organism: Carassius auratus (Goldfish)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi , Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala , Osteoglossocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HAEGTYTSDISSFLRDQAAQNFVAWLKSGQPKQE
Length: 34(88-121)
Propeptide: MKGAQYLAGLLLLLFVQNSICVPLQDYHTSTETVEGLLARGQGFTTAKRHSEGTFSNDYSKYLETRRAQDFVEWLMNSKSNGGSAKRHAEGTYTSDISSFLRDQAAQNFVAWLKSGQPKQE
Signal peptide: MKGAQYLAGLLLLLFVQNSIC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006446_AF2.pdb

hor006446_ESM.pdb

Mass:	439994	Formula:	C168H253N47O55
Absent amino acids:	CM	Common amino acids:	AQS
pI:	5.59	Basic residues:	4
Polar residues:	10	Hydrophobic residues:	11
Hydrophobicity:	-79.71	Boman Index:	-7321
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.71
Instability Index:	3104.71	Extinction Coefficient cystines:	6990
Absorbance 280nm:	211.82